Signaling Diseases

Ample number of diseases are caused by defects in signaling pathways. The nature of these defects and how they are induced varies enormously. Pathogenic organisms and viruses, many of which can interfere with signalling events, can cause some of these defects. There are many diseases that can be traced to deformity in the function of cell signalling pathways. The concept of signalsome remodelling and disease provides a framework for considering how deformity in signalling pathways can result in disease. It is convenient to separate these defects into phenotypic remodelling of the signalsome and genotypic remodelling of the signalsome. Most of the serious diseases in humans, such as hypertension, heart disease, diabetes and many forms of mental illness, seem to arise from subtle phenotypic modifications of signalling pathways. Such phenotypic remodelling amend the behaviour of cells so that their normal functions are subverted, leading to disease. Since it has proved difficult to clearly establish this relationship between signalsome remodelling and disease, there has been relatively little progress in designing effective treatments.

  • Pathogenic organism and viruses related disease in cell signaling
  • Phenotypic and genotypic remodelling of the signalsome
  • Cell proliferation and cell differentiation related disease
  • Cell proliferation and cell differentiation related disease

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