Modern Approach in Cell Signaling

The aim of research in signal transduction is to identify the functions of various signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made crucial grants to our understanding of cellular signaling. Despite, the single-gene approach does not take into account the full complexity of cell signaling. With the connections of omics techniques, huge progress has been made in understanding signaling networks.

The use of schemes for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation, help to settle down some general regulatory characteristics of multi-tiered signaling cascades, and illuminate the combinatorial nature of signaling specificity in cell differentiation. Cellular kinase signal transduction pathways are muddled in the regulation of many important cellular processes such as cell survival, differentiation and apoptosis. 

  • Protein profiling and phosphorylation profiling
  • Molecular profiling including genomics, proteomics, and post translational modifications
  • Key signaling networks in cancer
  • Cell signaling pathways and HIV therapeutics

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