Cell Signaling Dynamics

Cell signaling is highly complex system and extremely specific process that governs many important functions in bacterial and human cells. Each signaling process involves multiple steps, and the major research challenge is to perform suitable experiments and modeling not only to study the individual steps, but also to understand how these steps are perfectly coordinated and regulated to produce the end point response. 

Biological networks are complex and dynamic systems that enable living cells to sense and respond to changes in their immediate environment. Although the main components of biological networks have been studied in detail, it remains unclear how cells decode, integrate cell signals and make cell decisions. The Cell Signaling Dynamics group combines both mathematical modeling and experimental approaches to unravel the mechanisms of molecular networks by which extrinsic and intrinsic signals control cell proliferation and differentiation at a systems level.

  • Cell to cell signaling
  • Systems Biology of TGF-β Signaling Dynamics
  • Systems analysis of the adaptation in TGF-β signaling
  • Innate and adaptive immune response
  • Host interactions related to cell signaling
  • Bacterial virulence and drug resistance
  • Molecular mechanism of kinase activity
  • Organelle crosstalk in membrane dynamics and cell signaling

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