Annual Summit on Cell Signaling and Cancer Therapy September 27-28, 2017
(10 Plenary Forums - 1Event)
Chicago, Illinois, USA

Track 1: Cell Signaling

Cell signaling is highly complex system and extremely specific process that governs many important functions in bacterial and human cells. Each signaling process involves multiple steps, and the major research challenge is to perform suitable experiments and modeling not only to study the individual steps, but also to understand how these steps are perfectly coordinated and regulated to produce the end point response. Cellular Signaling publishes original research describing fundamental and novel findings on the mechanisms, actions and structural components of cellular signaling systems. It is the mechanism by which stimuli are transmitted via signaling cascade to effectors molecules that orchestrate the appropriate response.

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Track 2: Modes of Signaling & Signaling Pathways

In multicellular organisms, cells use many kinds of extracellular molecules to send signals and communicate with one another. All signal molecules act as ligands and that bind to receptors expressed by their target cells, there is noticeable variation in the structure and function of the various types of molecules that play as signal transmitters. Cells communicate with each other via direct contact  juxtacrine signaling, paracrine signaling, and endocrine signaling. Cell signaling can be divided to be mechanical and biochemical based on the type of the signal. Some cell–cell communication requires direct cell–cell contact. Some cells can form gap junctions that connect their cytoplasm  to the cytoplasm of adjacent cells. In cardiac muscle, gap junctions between adjacent cells provides for action potential  propagation from the cardiac pacemaker region of the heart to spread and coordinately cause contraction of the heart.

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Track 3: Protein Signaling & Neuronal Signaling

Protein and intracellular signaling peptides generally are peptides and proteins which are involved in transmission of signals or signal transduction across the membrane of all cells. Signals in the form of second messengers, hormones, proteins and other biological molecules which are recognized by cell surface receptors that transfer their response to other intracellular signaling peptides and Protein like Transcriptor Factor. The broadly distributed monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) exerts its actions via 14 classes of receptor. In many signaling pathways, many type of factors have been isolated by molecular genetic studies and whole genome analysis.

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Track 4: Signaling Defect and Diseases

Ample number of diseases is caused by defects in signaling pathways. The nature of these defects and how they are induced varies excessively. Pathogenic organisms and viruses, many of which can obstruct with signaling events, cause some of these defects. The thought of signalsome remodeling and disease provides a schema for considering how defects in signaling pathways can conclude in disease. Most of the severe diseases in humans, such as hypertension, diabetes and many forms of mental illness, look to appear from subtle phenotypic modifications of signaling pathways.

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Track 5: Cell Adhesion and Cell Communication

Adhesion of cells is a prime factor of the architecture of many tissues. Cell adhesion is the process cells interact and attach to a  surface, substrate or another cell, mediated by interactions between molecules of the cell surface. Cell adhesion happens from the action of transmembrane glycoproteins, and these include selectins, integrins, syndecans and cadherins. Cellular adhesion is essential in maintaining multicellular structure. Cell adhesion includes like Genomic and Functional Screening. Cell adhesion is also essential for the pathogenesis of infectious organisms. Viruses also have adhesion molecules required for viral binding to host cells like in influenza virus. Dysfunction of cell-adhesion and cell-migration occurs during cancer metastasis.

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Track 6: Advanced Approach in Cell Signaling

The goal of research in signal transduction is to identify the functions of various signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made crucial grants to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the connections of omics techniques, huge progress has been made in understanding signaling networks. Advanced approach of cell signaling includes protein profiling and phosphorylation profiling and in this section also has molecular profiling which includes genomics proteomics and post translation modifications. By the process of cell signaling pathways, HIV may be cured.

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Track 7:Cancer Therapy

There are many treatments for cancer. The goal of any treatment is to remove cancerous cells to try to ensure cancer doesn’t return. It can be challenging because even if just one cancerous cells remains after treatment. A lot of experimental cancer treatments are also under development. Sometimes this can be proficient by surgery, radiotherapy, chemotherapy but the susceptibility of cancers to infect adjacent tissue or to spread to distant sites by microscopic metastasis usually limits its effectiveness. Biopsy is another option for cancer treatment.

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Track 8:  Radiation Therapy

It is the use of ionizing radiation that means high doses of radiation to kill cancer cells and shrink tumors. It can be administered externally via external beam radiotherapy  or internally via brachytherapy. Radiation therapy kills malignant cells by the process of linear accelerator. High Precision Radiation Therapy techniques used for treatment such as 3D CRT, TBI, IMRT, IGRT, Stereotactic Radio surgery (SRS), Stereotactic Radiation Therapy (SRT) and VMAT to minimize damage to normal tissue. Radiation therapy may be used to treat approximate each type of solid tumor, comparing cancers of the brain, breast, cervix, larynx, liver, lung, pancreas, prostate or soft  tissue sarcomas.

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Track 9: Chemotherapy

Chemotherapy is a class of cancer treatment that uses one or more anti-cancer drugs as part of a standardized chemotherapy regimen. Chemotherapy is one of the major categories of medical oncology that is devoted to pharmacotherapy. Chemotherapy is considered a systemic therapy. It means it may affect your entire body. Chemotherapy is one of the major categories of medical oncology.

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Track 10: Immunotherapy & Targeted Therapy

It is a treatment of disease to suppress induces or enhances the immune response. Few types of immunotherapy are also sometimes called biologic therapy or biotherapy.  Suppression immunotherapies is a part of this in which Immunosuppressive drugs help manage organ transplantation and autoimmune disease. Therapies such as granulocyte colony-stimulating factor , interferons, imiquimod and cellular membrane fractions from bacteria are licensed for medical use. Immunotherapy also includes the monoclonal antibodies, adoptive cell therapies and cancer vaccines. The unveiling of the sequence of the human genome, upgrading bioinformatics tools and optimized immunological analytical tools have made it possible to screen any given protein for immunogenic epitopes. Cancer immunotherapy introduces a diverse set of therapeutic strategies designed to induce the patient's own immune system to fight the tumor. Vaccines to generate specific immune responses in research of malignant melanoma and renal cell carcinoma. Sipuleucel-T is a vaccine-like strategy is also used for prostate cancer. Allogeneic hematopoietic stem cell transplantation also a class of immunotherapy.

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Track 11: Cancer Stem Cell Therapy

A stem cell transplant can be used to infuse healthy stem cells into the body to stimulate new bone marrow growth, suppress the disease, and decrease the possibility of a relapse. Stem cells can be found in the bone marrow, circulating blood and umbilical cord blood. CSCs are tumor forming in contrast to other non tumorigenic cancer cells. Such cells are hypothesized to endure in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. For cancer stem cell therapy many models available like tumor propagation model, mechanistic and mathematical model and mathematical model is based on cell compartment method. CSCs include fluorescence-activated cell sorting.

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Track 12: Common & Novel Therapies in Cancer Treatment

The analysis of cancer has undergone evolutionary changes as understanding of the underlying biological processes has risen. Tumor removal surgeries have been documented in ancient Egypt, hormone therapy and radiation therapy were advanced in the late 19th Century. Chemotherapy, immunotherapy and newer targeted therapies are products of the 20th century. External radiation and radiation implants under the radiation therapy. Common therapies include the biologic therapies, targeted therapies, complementary and alternative therapy also.

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Track 13: System Biology

Systems biology is the study of biological systems whose behavior cannot be diminished to the linear sum of their parts function. System biology does not accordingly include vast number of components or large datasets, like in genomics or connectomics, but usually requires quantitative modeling methods imitated from physics. This ability to design predictive, multiscale models to discover new biomarkers for disease, stratify patients based on unique genetic profiles, and target drugs and other treatments. Systems biology, creates the potential for entirely new kinds of analysis, and drives constant innovation in biology-based technology and computation. Computational biology is a main part of this field.

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Importance & Scope

Cell signaling and cancer therapy is a Major Field in modern medical Practice and Diagnosis. Cell signaling and cancer therapy is bound with the system biology, computational biology, genomics proteomics, metabolomics, drug designing clinical trials, bacterial pathogenesis and microbial immunization. This field includes the Cell Identification, Cell Viability, Cell Signaling Pathway/Signal Transduction, Cell Proliferation, Cell Interaction,  Target Identification and Validation, Single-cell Analysis. Cell signaling and cancer therapy includes the investigation of the harming effect of ailment on cells and tissues and the route in which the body looks to secure and repair itself. The global cell analysis market is expected to reach USD 26.0 Billion by 2020 from USD19.0 Billion in 2015, growing at a CAGR of 6.56% from 2015 to 2020.Prominent players in the cell market are BD Biosciences, Danaher Corporation, GE Healthcare, Miltenyi Biotec, pluriSelect, STEMCELL Technologies, Sigma-Aldrich Corporation and Thermo Fisher Scientific, Inc.

Cell signaling and cancer therapy 2017 conference will cover the new research Techniques and concentrates on Exhibition of new Products introduced by the biotech Laboratories. Also covers the increase in need for cancerous patient. Cell signaling and cancer therapy brings basic and Clinical research into mechanisms of Diseases which is caused by cancer.

Why Chicago?

Chicago  is the third most popular city in the United States. With over 2.7 million residents, it is the most populous city in the state of Illinois and the Midwestern United States, and the county seat of Cook County. The study and research of the Clinical Genetics is top in USA when compared to the Europe and Asia. Clinical Genetics related companies and products are mostly found in USA. The most developed technologies related to Genetics are used in universities in USA. There are 5 research institutes and 51 research centers. Chicago has been a world center of higher education and research with many universities that are in the city proper or in the immediate environs. These institutions consistently rank among the top National Universities in the United States, as determined by U.S. News & World Report. Top universities in Chicago are the University of Chicago, Illinois Institute of Technology, Northwestern University, Loyola University Chicago and DePaul University . The Major Biotech Companies in chicago are: Biosceptre, Charles River Laboritries, Circassia Pharmaceuticals, Errant Gene Therapeutics, Novian Health, Neurodon, Maroon Biotech.

Cell Signaling Analysis Market by Product

The global cell-based assays market is expected to grasp USD 18,329.37 Million by 2020 from USD 10,799.53 Million in 2015, growing at a CAGR of 11.16% between 2015 and 2020. The global pharmaceutical industry is expected to rise at a CAGR between 7% and 12% in the forecast period 2014 to 2019.The global oncology drug market is expected to reach $ 150 billion by 2020 from $ 107 billion in 2015 entering annual growth rate of 7.5-10.5 percent through 2020, according to a new study. The global Cancer/Tumor Profiling market is poised to reach USD 61.87 Billion by 2021 from USD 25.82 Billion in 2016, at a CAGR of 19.1% from 2016 to 2021.

Cancer Therapy Analysis Market by Product

Cancer Biological Therapy Market size is expected to reach USD 100 billion by 2023; as per a new research report by Global Market Insights, Increasing incidence rates and increased adoption of biologic therapy will drive global cancer biological therapy market size It is estimated by the ACS that 180,890 prostate cancer and 246,660 breast cancer cases will be diagnosed in 2016 in the U.S. Cancer growth blockers market was over USD 18 billion in 2015, and is expected to rise at 5.8% CAGR from 2016 to 2023. Bispecific monoclonal antibodies are anticipated to grow at 6.5% CAGR from 2016 to 2023. The global Cancer therapy market is estimated to grow at 17.6% CAGR to reach $52.2billion by 2021. Breast cancer therapy is the largest market expected to reach $30.8 billion by 2016 at an estimated CAGR of 15%.